The global distribution and spread of the mobilized colistin resistance gene mcr-1
Wang, R., van Dorp, L., Shaw, L. P., Bradley, P., Wang, Q., Wang, X. et al. 2018. The global distribution and spread of the mobilized colistin resistance gene mcr-1. Nature Communications, 9 (1): 1179. doi:10.1038/s41467-018-03205-z.
Colistin represents one of the few available drugs for treating infections caused by carbapenem-resistant Enterobacteriaceae. As such, the recent plasmid-mediated spread of the colistin resistance gene mcr-1 poses a significant public health threat, requiring global monitoring and surveillance. Here, we characterize the global distribution of mcr-1using a data set of 457 mcr-1-positive sequenced isolates. We find mcr-1in various plasmid types but identify an immediate background common to all mcr-1 sequences. Our analyses establish that all mcr-1elements in circulation descend from the same initial mobilization of mcr-1 by an ISApl1 transposon in the mid 2000s (2002–2008; 95% highest posterior density), followed by a marked demographic expansion, which led to its current global distribution. Our results provide the first systematic phylogenetic analysis of the origin and spread of mcr-1, and emphasize the importance of understanding the movement of antibiotic resistance genes across multiple levels of genomic organization.
Publiée : 10/04/2018